On-label indications:
- Air or gas embolism
- Carbon monoxide poisoning
- Clostridial myositis and myonecrosis (gas gangrene)
- Crush injury, compartment syndrome, and other acute traumatic ischemias
- Decompression sickness
- Arterial insufficiencies (enhancement of healing in selected problem wounds)
- Delayed radiation injury (soft tissue and bony necrosis)
- Diabetic lower extremity ulcers
- Idiopathic sudden sensorineural hearing loss
- Chronic refractory osteomyelitis
- Compromised grafts and flaps
Off-label indications:
- Acute thermal burn injury
- Neuroblastoma stage IV
- Multiple sclerosis
- Autism
- Cerebral palsy
- Traumatic brain injury
- Stroke rehabilitation
- Bone grafts
- Acute peripheral artery disease
- Coronary artery disease
- Migraine headaches
- Chronic fatigue syndrome
